Peptidyl-tyrosine dephosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-tyrosine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM1, SIRT6, and ACO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ICAM1 grouped by Peptidyl-tyrosine dephosphorylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ICAM1 →	+2.437	+0.293	<.001	.004	3	5
SKIN	SIRT6 →	-0.547	-1.055	<.001	<.001	3	3
BONE	ACO2 →	-0.887	-0.496	.007	.007	3	3
BONE	TMTC4 →	-1.486	-0.401	<.001	.003	3	3
BONE	ELOVL7 →	+1.405	+0.334	.001	.004	3	3
BONE	PCCA →	-1.385	-0.341	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICAM1 by Peptidyl-tyrosine dephosphorylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →