Positive regulation of hippo signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of hippo signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DLG5_S264, MRC2, and SLK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hippo signaling activity versus DLG5_S264 in BRCA (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DLG5_S264 →	+0.603	+0.071	.001	<.001	3	6
CCRCC	MRC2 →	+0.335	+0.049	.004	<.001	3	5
PDAC	SLK →	+0.248	+0.086	.001	<.001	3	5
BRCA	DLG5_S803 →	+0.501	+0.051	<.001	.001	3	5
BRCA	FRMD6_S544 →	+0.777	+0.058	<.001	.002	3	5
LSCC	PLAU →	+0.497	+0.082	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035332 vs DLG5_S264 — BRCA

Explore this scatter interactively →