Positive regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM5, TBC1D30, and PRODH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEACAM5 grouped by Positive regulation of hippo signaling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CEACAM5 →	+4.992	+0.926	.002	.007	3	4
BREAST	TBC1D30 →	+1.470	+0.352	<.001	.009	3	4
LUNG_NSCLC_LUAD	PRODH →	+1.652	+0.454	.004	.009	3	4
LUNG_NSCLC_LUAD	DNAJA3 →	+0.384	+0.415	.005	.006	3	4
LUNG_NSCLC_LUAD	AKAP1 →	+0.482	+0.490	.001	.001	3	4
SKIN	C1orf122 →	-0.366	-0.457	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEACAM5 by Positive regulation of hippo signaling activity — STOMACH

Explore this box plot interactively →