Hair cell differentiation

Across TCGA cell cohorts, RNA activity of the Hair cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VANGL2, ADCK2, and SLC38A11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VANGL2 grouped by Hair cell differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VANGL2 →	-0.406	-0.484	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ADCK2 →	+0.204	+0.515	.002	.001	3	4
OVARY	SLC38A11 →	+0.342	+0.468	<.001	.007	3	3
BLOOD_Leukemia	SPPL2A →	+0.235	+0.690	<.001	.005	3	3
OVARY	TAP2 →	-0.160	-0.406	.008	.006	3	3
BLOOD_Lymphoma	ROPN1 →	+0.160	+0.471	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VANGL2 by Hair cell differentiation activity — STOMACH

Explore this box plot interactively →