Trunk segmentation

Across TCGA patient cohorts, RNA activity of the Trunk segmentation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN1, F13A1, and SERPINH1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trunk segmentation activity versus CAVIN1 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CAVIN1 →	+0.764	+0.112	<.001	<.001	3	7
GBM	F13A1 →	+0.875	+0.127	<.001	<.001	3	7
BRCA	SERPINH1 →	+0.535	+0.053	<.001	<.001	3	7
CCRCC	SULF1 →	+0.969	+0.073	<.001	.009	3	7
OV	TES_S168 →	+0.594	+0.088	<.001	<.001	3	7
BRCA	CNN2 →	+0.742	+0.076	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035290 vs CAVIN1 — OV

Explore this scatter interactively →