Trunk segmentation

Across TCGA cell cohorts, RNA activity of the Trunk segmentation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A11, PROCR, and SH3TC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A11 grouped by Trunk segmentation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	S100A11 →	-3.003	-1.142	.009	.003	3	4
SKIN	PROCR →	-1.842	-0.918	.001	.006	3	4
BONE	SH3TC2 →	-2.590	-1.247	<.001	.005	3	4
KIDNEY	ZIC5 →	+0.794	+1.357	<.001	<.001	3	4
BLOOD_Myeloma	POMGNT1 →	-0.987	-1.794	.002	<.001	3	4
BLOOD_Leukemia	TIGD3 →	+0.605	+1.036	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A11 by Trunk segmentation activity — BLOOD_Leukemia

Explore this box plot interactively →