Segmentation

Across TCGA patient cohorts, RNA activity of the Segmentation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, SAR1B, and SH3BP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segmentation activity versus LAMB1 in OV (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMB1 →	+0.356	+0.025	.003	<.001	3	6
LSCC	SAR1B →	-0.206	-0.024	<.001	<.001	3	6
PDAC	SH3BP4 →	+0.180	+0.021	<.001	<.001	3	5
BRCA	C1S →	+0.510	+0.024	.001	<.001	3	5
LSCC	LCP2 →	-0.358	-0.033	<.001	<.001	3	5
OV	NID1 →	+0.477	+0.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035282 vs LAMB1 — OV

Explore this scatter interactively →