Segmentation

Across TCGA patient cohorts, RNA activity of the Segmentation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACACB, MIEF2, and SLC16A11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segmentation activity versus ACACB in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACACB →	+0.804	+0.391	.001	.001	3	4
LUAD	MIEF2 →	+0.375	+0.254	<.001	.007	3	4
COAD	SLC16A11 →	+0.348	+0.679	<.001	.002	3	4
CCRCC	TUT1 →	+0.176	+0.262	.004	<.001	3	3
CCRCC	RIBC1 →	+0.436	+0.311	.003	.003	3	3
PDAC	SAC3D1 →	+0.216	+0.447	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035282 vs ACACB — BRCA

Explore this scatter interactively →