Segmentation

Across TCGA cell cohorts, RNA activity of the Segmentation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCHF1, JRKL, and EEF1B2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARCHF1 grouped by Segmentation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MARCHF1 →	+0.711	+0.263	<.001	.002	3	3
LUNG_NSCLC_LUSC	JRKL →	+0.730	+0.312	<.001	.008	3	3
OVARY	EEF1B2 →	+0.527	+0.725	.002	.001	3	3
OVARY	GCC2 →	-0.625	-0.862	.005	.002	3	3
OVARY	FHAD1 →	-0.684	-0.609	.009	.009	3	3
OVARY	FGFBP3 →	+0.515	+0.676	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARCHF1 by Segmentation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →