Segmentation

Across TCGA cell cohorts, RNA activity of the Segmentation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF12, CIB2, and HOXB13, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segmentation activity versus SRSF12 in OVARY (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SRSF12 →	-1.061	-0.056	.003	.006	3	8
CNS	CIB2 →	-1.108	-0.031	.001	.003	3	7
BONE	HOXB13 →	-3.060	-0.078	<.001	.001	3	7
SKIN	ZNF529 →	-0.870	-0.049	.001	.002	3	7
PANCREAS	PLXNA2 →	+1.376	+0.038	<.001	.007	3	7
OVARY	SEMA4G →	-1.346	-0.065	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035282 vs SRSF12 — OVARY

Explore this scatter interactively →