Exocrine system development

Across TCGA patient cohorts, RNA activity of the Exocrine system development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LUM, PRELP, and BGN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine system development activity versus LUM in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LUM →	+0.780	+0.035	<.001	.005	3	9
CCRCC	PRELP →	+1.129	+0.049	<.001	<.001	3	9
CCRCC	BGN →	+0.839	+0.048	<.001	<.001	3	9
LSCC	RCN3 →	+0.495	+0.060	<.001	<.001	3	8
CCRCC	SERPINF1 →	+0.832	+0.061	<.001	<.001	3	8
CCRCC	TIMP2 →	+0.571	+0.051	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035272 vs LUM — CCRCC

Explore this scatter interactively →