Exocrine system development

Across TCGA patient cohorts, RNA activity of the Exocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHPS, MANBA, and EGFR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine system development activity versus DHPS in COAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DHPS →	+0.415	+0.687	.004	<.001	3	4
LUAD	MANBA →	+0.286	+0.225	.008	.003	3	4
GBM	EGFR →	+2.192	+0.295	<.001	<.001	3	4
BRCA	PDGFC →	+0.670	+0.453	.003	.001	3	4
GBM	EGFR-AS1 →	+2.099	+0.299	<.001	<.001	3	4
HNSC	CDK14 →	+0.588	+0.155	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035272 vs DHPS — COAD

Explore this scatter interactively →