Exocrine system development

Across TCGA cell cohorts, RNA activity of the Exocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB1, MIER3, and WLS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine system development activity versus TGFB1 in LARGE_INTESTINE (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TGFB1 →	+1.383	+0.092	<.001	.004	3	7
BLOOD_Lymphoma	MIER3 →	-0.786	-0.175	<.001	.003	3	7
OVARY	WLS →	+2.734	+0.159	.001	.001	3	6
URINARY_TRACT	GLIPR1 →	+2.019	+0.116	.003	.006	3	6
LIVER	MGAT4A →	-2.157	-0.185	.008	.003	3	6
LUNG_NSCLC_LUAD	RABAC1 →	+0.613	+0.066	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035272 vs TGFB1 — LARGE_INTESTINE

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