Exocrine system development

Across TCGA cell cohorts, RNA activity of the Exocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNB2, LYPD3, and CYREN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine system development activity versus GNB2 in SOFT_TISSUE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GNB2 →	+0.551	+1.322	.001	<.001	3	4
URINARY_TRACT	LYPD3 →	-3.948	-1.468	.001	.004	3	4
SKIN	CYREN →	+0.888	+1.483	.002	<.001	3	4
LARGE_INTESTINE	THTPA →	+1.131	+1.739	<.001	<.001	3	4
URINARY_TRACT	TANGO6 →	+0.763	+1.638	.001	<.001	3	3
URINARY_TRACT	KIAA1217 →	-1.627	-1.598	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035272 vs GNB2 — SOFT_TISSUE

Explore this scatter interactively →