Endocrine system development

Across TCGA patient cohorts, RNA activity of the Endocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMRN1, NME2, and SDAD1P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine system development activity versus MMRN1 in BRCA (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMRN1 →	+0.768	+0.143	.001	.003	2	5
BRCA	NME2 →	-0.504	-0.129	<.001	.007	3	4
COAD	SDAD1P1 →	+0.198	+0.422	.005	.004	3	4
BRCA	CPED1 →	+0.752	+0.167	<.001	<.001	3	3
BRCA	F13A1 →	+1.106	+0.133	<.001	.005	3	3
BRCA	RCBTB2 →	+0.413	+0.127	.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035270 vs MMRN1 — BRCA

Explore this scatter interactively →