Endocrine system development

Across TCGA cell cohorts, RNA activity of the Endocrine system development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPAS1, CEBPZOS, and HYI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPAS1 grouped by Endocrine system development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NPAS1 →	+1.248	+1.282	.005	.007	2	5
OESOPHAGUS	CEBPZOS →	+0.627	+0.983	.002	.001	3	4
CNS	HYI →	-0.914	-0.639	.006	.001	3	4
BLOOD_Leukemia	SLC20A1 →	+1.059	+0.925	.005	.004	3	3
SOFT_TISSUE	PRPF19 →	-0.641	-1.486	.002	.001	3	3
CNS	GPSM3 →	-1.221	-0.893	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPAS1 by Endocrine system development activity — BONE

Explore this box plot interactively →