Protein O-linked mannosylation

Across TCGA patient cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOGARAM1, MON2, and MICAL3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked mannosylation activity versus TOGARAM1 in DLBC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TOGARAM1 →	+1.028	+0.043	<.001	<.001	3	32
UVM	MON2 →	+0.965	+0.024	<.001	<.001	3	32
DLBC	MICAL3 →	+1.402	+0.050	<.001	<.001	3	31
KIRP	TNRC6B →	+0.849	+0.046	<.001	<.001	3	31
DLBC	EP300 →	+1.724	+0.044	<.001	<.001	3	31
THYM	SPIN1 →	+1.120	+0.045	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035269 vs TOGARAM1 — DLBC

Explore this scatter interactively →