Protein O-linked mannosylation

Across TCGA patient cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBXAS1, FERMT3, and GMIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked mannosylation activity versus TBXAS1 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TBXAS1 →	-0.408	-0.059	.003	<.001	3	7
CCRCC	FERMT3 →	-0.464	-0.036	<.001	<.001	3	7
LSCC	GMIP →	-0.355	-0.060	<.001	<.001	3	7
LSCC	LRCH4 →	-0.255	-0.062	<.001	<.001	3	7
LSCC	RHBDF2_S385 →	-0.419	-0.060	.006	<.001	3	6
LSCC	S100A9_T113 →	-0.720	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035269 vs TBXAS1 — LSCC

Explore this scatter interactively →