Protein O-linked mannosylation

Across TCGA patient cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM163, DSCAM, and CPA4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked mannosylation activity versus TMEM163 in PDAC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM163 →	+0.438	+0.415	.005	.007	3	3
GBM	DSCAM →	+0.730	+0.144	.004	<.001	3	3
HNSC	CPA4 →	+1.258	+0.572	.008	.004	3	2
LSCC	TMEM273 →	-0.462	-0.715	.009	.009	3	2
LSCC	RNU6-1174P →	-0.415	-0.587	.001	.005	3	2
LSCC	IGLVI-68 →	-0.122	-0.637	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035269 vs TMEM163 — PDAC

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