Protein O-linked mannosylation

Across TCGA cell cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ6, ZFYVE21, and TSPAN7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COQ6 grouped by Protein O-linked mannosylation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COQ6 →	-1.041	-1.682	.004	.005	3	5
SOFT_TISSUE	ZFYVE21 →	-0.960	-1.395	.004	.004	3	4
SOFT_TISSUE	TSPAN7 →	+3.081	+1.602	.001	.002	3	4
SOFT_TISSUE	TMEM234 →	-1.058	-2.093	.004	<.001	3	4
SOFT_TISSUE	COQ2 →	-1.045	-1.791	.004	.001	3	4
SOFT_TISSUE	ZNF839 →	-1.083	-1.917	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COQ6 by Protein O-linked mannosylation activity — SOFT_TISSUE

Explore this box plot interactively →