Protein O-linked mannosylation

Across TCGA cell cohorts, RNA activity of the Protein O-linked mannosylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf78, SMARCA1, and TMEM187, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C17orf78 grouped by Protein O-linked mannosylation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C17orf78 →	-0.344	-0.072	.003	.009	3	4
UPPER_AERODIGESTIVE_TRACT	SMARCA1 →	+0.146	+0.109	.009	.003	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM187 →	+0.145	+0.098	.009	.009	3	4
OVARY	MOB3B →	+0.285	+0.111	.001	.003	3	4
LARGE_INTESTINE	BAG2 →	-0.155	-0.060	<.001	.002	3	4
SKIN	VPS37A →	-0.178	-0.069	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C17orf78 by Protein O-linked mannosylation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →