Organ growth

Across TCGA patient cohorts, RNA activity of the Organ growth pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAYN, MEF2C, and CNRIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ growth activity versus LAYN in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAYN →	+0.878	+0.940	.004	<.001	3	6
HNSC	MEF2C →	+0.802	+0.716	.006	<.001	3	6
OV	CNRIP1 →	+0.739	+0.669	<.001	<.001	3	6
OV	BCL6B →	+0.691	+0.787	<.001	<.001	3	6
PDAC	EFEMP2 →	+0.355	+0.490	.003	.009	3	6
OV	ABCC9 →	+0.882	+0.808	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035265 vs LAYN — OV

Explore this scatter interactively →