Organ growth

Across TCGA cell cohorts, RNA activity of the Organ growth pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIF1L, FBRSL1, and DIPK1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ growth activity versus AIF1L in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AIF1L →	-1.999	-0.929	.002	.003	3	5
BLOOD_Leukemia	FBRSL1 →	-0.676	-0.499	<.001	.001	3	5
BLOOD_Leukemia	DIPK1B →	-1.661	-0.605	<.001	.002	3	5
SOFT_TISSUE	TRAM2 →	+1.992	+1.969	.006	<.001	3	4
STOMACH	MRPS10 →	+0.886	+1.318	.008	.004	3	4
LARGE_INTESTINE	TARDBP →	+0.494	+0.866	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035265 vs AIF1L — BREAST

Explore this scatter interactively →