Multicellular organism growth

Across TCGA patient cohorts, RNA activity of the Multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRELID3BP4, TJP1, and CHKB, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organism growth activity versus PRELID3BP4 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRELID3BP4 →	+0.179	+0.615	.002	.009	3	2
BRCA	TJP1 →	-1.406	-0.300	<.001	.008	3	2
COAD	CHKB →	+0.206	+0.608	.001	.003	3	1
COAD	NPR3 →	+1.015	+0.790	<.001	.009	3	1
COAD	IFNK →	+0.050	+0.992	.005	<.001	3	1
COAD	ATP2B2 →	+0.042	+0.689	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035264 vs PRELID3BP4 — COAD

Explore this scatter interactively →