Ectopic germ cell programmed cell death

pathway activity — cross-omics
GO:0035234Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ectopic germ cell programmed cell death pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GCA, C1R, and MECP2_S423, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADGCA →+0.446+0.042.004.00235
CCRCCC1R →+0.470+0.046<.001.00235
PDACMECP2_S423 →+0.515+0.051.003.00234
LSCCSOX6_S411 →-1.072-0.068<.001<.00134
GBMSP100_S407 →+0.519+0.070<.001<.00134
OVPRTN3 →+0.890+0.062.004.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration