Regulation of tube size

Across TCGA patient cohorts, RNA activity of the Regulation of tube size pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF7, ADAM33, and ABCC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tube size activity versus FGF7 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGF7 →	+1.533	+0.887	<.001	<.001	3	7
BRCA	ADAM33 →	+0.932	+0.252	<.001	<.001	3	6
LSCC	ABCC9 →	+1.031	+0.857	<.001	<.001	3	6
BRCA	S1PR1 →	+0.923	+0.273	<.001	<.001	3	6
OV	KCNMB1 →	+0.397	+0.391	.003	.006	3	6
BRCA	DIPK2B →	+0.755	+0.293	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035150 vs FGF7 — LSCC

Explore this scatter interactively →