Regulation of tube size

Across TCGA cell cohorts, RNA activity of the Regulation of tube size pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPSB1, RPL38, and PI3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tube size activity versus SPSB1 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPSB1 →	+1.363	+0.210	.002	.001	3	6
LIVER	RPL38 →	-0.764	-0.306	<.001	<.001	3	5
LIVER	PI3 →	+1.592	+0.274	.007	.001	3	4
LIVER	CTRC →	+0.284	+0.281	<.001	<.001	3	4
LUNG_NSCLC_LUAD	DIO2 →	+2.707	+0.179	<.001	.001	3	4
OESOPHAGUS	TRIM17 →	-0.532	-0.341	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035150 vs SPSB1 — STOMACH

Explore this scatter interactively →