Forelimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN8, TLN2, and DAPK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forelimb morphogenesis activity versus SEPTIN8 in BRCA (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN8 →	+0.237	+0.020	<.001	.001	3	7
LSCC	TLN2 →	+0.559	+0.057	<.001	<.001	3	7
UCEC	DAPK3 →	+0.653	+0.096	<.001	<.001	3	7
UCEC	DIP2C →	+0.367	+0.060	<.001	<.001	3	7
UCEC	EML1 →	+0.418	+0.061	<.001	<.001	3	7
UCEC	PARVA →	+0.610	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035136 vs SEPTIN8 — BRCA

Explore this scatter interactively →