Forelimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPR2, FPR1, and NABP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forelimb morphogenesis activity versus FPR2 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FPR2 →	-0.678	-0.760	.001	.002	3	7
GBM	FPR1 →	-1.385	-0.824	<.001	.004	3	5
LUAD	NABP1 →	-0.661	-0.887	<.001	<.001	3	5
LSCC	FCGR2A →	-0.569	-0.725	<.001	<.001	3	5
BRCA	ARPC2 →	-0.338	-0.614	<.001	<.001	3	5
LSCC	SAA2 →	-0.962	-0.755	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035136 vs FPR2 — LSCC

Explore this scatter interactively →