Forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD11, ZNF621, and MRPS9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDCD11 grouped by Forelimb morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDCD11 →	+0.692	+1.255	.004	.002	3	4
LARGE_INTESTINE	ZNF621 →	+0.747	+1.251	<.001	<.001	3	3
SOFT_TISSUE	MRPS9 →	+0.518	+1.659	<.001	<.001	3	3
SOFT_TISSUE	NOLC1 →	+0.420	+0.982	.007	.002	3	3
LUNG_SCLC	VCPKMT →	-0.770	-1.139	.009	.002	3	3
LUNG_SCLC	HEATR4 →	-0.864	-1.309	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDCD11 by Forelimb morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →