Forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPF1, TCP10L3, and RNF10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPF1 grouped by Forelimb morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UPF1 →	-0.302	-0.999	<.001	.003	3	3
LUNG_NSCLC_LUAD	TCP10L3 →	+0.222	+1.777	.007	<.001	3	2
LUNG_NSCLC_LUAD	RNF10 →	+0.177	+1.759	.005	<.001	3	2
LUNG_NSCLC_LUAD	TSSK6 →	-0.220	-1.086	.006	.004	3	2
LUNG_NSCLC_LUAD	EP400 →	-0.537	-1.560	.006	.002	3	2
SKIN	CLIP2 →	-0.386	-1.293	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPF1 by Forelimb morphogenesis activity — BREAST

Explore this box plot interactively →