Forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Forelimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA12, KIF16B, and BCL2L2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forelimb morphogenesis activity versus NDUFA12 in CNS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NDUFA12 →	+0.643	+1.135	.005	.004	3	3
BREAST	KIF16B →	-1.045	-0.754	.002	.004	3	3
LARGE_INTESTINE	BCL2L2 →	-0.876	-1.383	.009	.001	3	2
CNS	CRNKL1 →	-0.770	-1.252	.006	<.001	2	3
CNS	CLCC1 →	-0.399	-1.252	.001	<.001	3	2
CNS	CORO6 →	+1.883	+1.609	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035136 vs NDUFA12 — CNS

Explore this scatter interactively →