Embryonic forelimb morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic forelimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF703, CCDC38, and SULT1A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic forelimb morphogenesis activity versus ZNF703 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF703 →	+1.597	+1.047	<.001	<.001	3	6
CCRCC	CCDC38 →	+0.140	+0.530	.009	.005	3	5
COAD	SULT1A3 →	+0.127	+0.254	<.001	.004	3	5
CCRCC	RNU6-834P →	+0.698	+0.597	.007	.006	3	5
BRCA	EXTL3-AS1 →	+0.385	+0.796	.002	<.001	3	4
HNSC	CBFA2T2 →	+0.498	+0.721	.007	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035115 vs ZNF703 — BRCA

Explore this scatter interactively →