Embryonic forelimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic forelimb morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRI3, CRTC1, and ZNF589, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRI3 grouped by Embryonic forelimb morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BRI3 →	-1.537	-0.705	<.001	<.001	3	4
STOMACH	CRTC1 →	-1.019	-1.051	.003	.003	3	4
LARGE_INTESTINE	ZNF589 →	+1.131	+1.444	<.001	<.001	3	4
PANCREAS	STOML1 →	+1.001	+1.211	.001	<.001	3	4
URINARY_TRACT	RPL13A →	+0.821	+1.492	.003	<.001	3	4
URINARY_TRACT	WDR43 →	+0.495	+1.378	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRI3 by Embryonic forelimb morphogenesis activity — BREAST

Explore this box plot interactively →