Genitalia morphogenesis

Across TCGA patient cohorts, RNA activity of the Genitalia morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN_S355, STK10, and CCDC88B_S597, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia morphogenesis activity versus SPN_S355 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPN_S355 →	-0.584	-0.101	.002	<.001	3	7
LSCC	STK10 →	-0.279	-0.114	<.001	<.001	3	7
LSCC	CCDC88B_S597 →	-0.735	-0.121	<.001	<.001	3	7
OV	CD48 →	-0.664	-0.075	.009	.008	2	8
LSCC	CORO1A →	-0.507	-0.139	<.001	<.001	3	7
LSCC	DOCK10 →	-0.315	-0.109	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035112 vs SPN_S355 — LSCC

Explore this scatter interactively →