Genitalia morphogenesis

Across TCGA patient cohorts, RNA activity of the Genitalia morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC7, SNORD9, and CCDC34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia morphogenesis activity versus ANAPC7 in LSCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANAPC7 →	+0.392	+0.315	<.001	.003	3	4
BRCA	SNORD9 →	+0.659	+0.240	.002	.003	3	4
LSCC	CCDC34 →	+0.492	+0.363	.002	.008	3	4
LSCC	GLS2 →	+0.184	+0.304	<.001	.004	3	4
OV	DIPK2B →	-0.520	-0.198	.001	.001	3	4
LSCC	GIMAP8 →	-0.419	-0.391	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035112 vs ANAPC7 — LSCC

Explore this scatter interactively →