Response to nicotine

Across TCGA patient cohorts, RNA activity of the Response to nicotine pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9, SP110_S256, and G6PD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nicotine activity versus S100A9 in PDAC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	S100A9 →	+0.890	+0.029	.001	<.001	3	4
PDAC	SP110_S256 →	-0.580	-0.030	.001	<.001	3	4
PDAC	G6PD →	+0.187	+0.018	.008	.006	3	4
PDAC	ILF2 →	-0.093	-0.025	.006	<.001	3	4
HNSC	PYCR2 →	+0.468	+0.042	.001	.002	3	4
BRCA	MSI2 →	+0.380	+0.033	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035094 vs S100A9 — PDAC

Explore this scatter interactively →