Response to nicotine

Across TCGA patient cohorts, RNA activity of the Response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH9, FAM155A, and COMTD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nicotine activity versus CDH9 in GBM (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDH9 →	+0.785	+0.202	<.001	<.001	3	4
GBM	FAM155A →	+0.691	+0.224	.005	<.001	3	4
LSCC	COMTD1 →	-0.669	-0.136	<.001	.001	3	4
GBM	VSTM2L →	+1.321	+0.237	<.001	<.001	3	3
GBM	ARRB1 →	+0.409	+0.161	.005	.001	3	3
GBM	SUOX →	+0.352	+0.229	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035094 vs CDH9 — GBM

Explore this scatter interactively →