Response to nicotine

Across TCGA cell cohorts, RNA activity of the Response to nicotine pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECSIT, WDR33, and EOGT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ECSIT grouped by Response to nicotine-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ECSIT →	+0.170	+0.431	.001	.004	3	5
SOFT_TISSUE	WDR33 →	+0.455	+1.323	<.001	.001	3	4
BREAST	EOGT →	-0.179	-0.980	.002	<.001	3	4
BREAST	ART5 →	-0.181	-0.620	<.001	.003	3	4
BREAST	PPARA →	-0.238	-0.720	.004	<.001	3	4
KIDNEY	UBR2 →	-0.265	-1.156	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ECSIT by Response to nicotine activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →