Response to nicotine

Across TCGA cell cohorts, RNA activity of the Response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2B3, HABP4, and STRIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nicotine activity versus SH2B3 in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SH2B3 →	+1.213	+1.173	.002	<.001	3	5
SKIN	HABP4 →	+0.748	+0.689	.007	.008	3	5
LUNG_NSCLC_LUAD	STRIP2 →	+1.395	+1.058	<.001	<.001	3	5
LUNG_NSCLC_LUAD	L3MBTL3 →	+0.962	+1.095	.005	.005	3	5
URINARY_TRACT	UBA3 →	+0.657	+1.483	<.001	<.001	3	4
STOMACH	COPG1 →	+0.591	+1.221	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035094 vs SH2B3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →