Maintenance of apical/basal cell polarity

Across TCGA patient cohorts, RNA activity of the Maintenance of apical/basal cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S685, DPYSL2, and SPIN1_S199, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of apical/basal cell polarity activity versus SYNPO_S685 in PDAC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SYNPO_S685 →	-0.888	-0.048	<.001	.004	3	5
HNSC	DPYSL2 →	-0.297	-0.082	<.001	<.001	3	5
LUAD	SPIN1_S199 →	-0.304	-0.069	.003	.002	3	5
BRCA	CXCL13 →	-0.842	-0.062	.006	.002	3	4
UCEC	AKT3 →	-0.614	-0.091	.001	.001	3	4
HNSC	PALM →	-0.381	-0.069	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035090 vs SYNPO_S685 — PDAC

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