Maintenance of apical/basal cell polarity

Across TCGA patient cohorts, RNA activity of the Maintenance of apical/basal cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA1, HBA2, and HBB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of apical/basal cell polarity activity versus HBA1 in CCRCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HBA1 →	+1.218	+0.363	<.001	<.001	3	8
PDAC	HBA2 →	+1.559	+0.258	<.001	<.001	3	7
HNSC	HBB →	+1.771	+0.252	<.001	<.001	3	7
CCRCC	HEMGN →	+0.465	+0.302	<.001	<.001	3	6
UCEC	SLC4A1 →	+0.496	+0.306	<.001	<.001	3	6
GBM	NR4A1 →	+1.236	+0.308	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035090 vs HBA1 — CCRCC

Explore this scatter interactively →