Maintenance of apical/basal cell polarity

Across TCGA cell cohorts, RNA activity of the Maintenance of apical/basal cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN20, U2AF1L4, and SLC5A6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN20 grouped by Maintenance of apical/basal cell polarity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZSCAN20 →	-0.517	-1.459	.002	.008	3	3
SKIN	U2AF1L4 →	-0.845	-1.530	<.001	<.001	3	3
LUNG_NSCLC_LUAD	SLC5A6 →	+0.979	+0.889	.004	.005	3	3
BREAST	WNK2 →	+3.106	+1.573	.001	.001	3	3
LUNG_SCLC	NRBP1 →	-1.232	-1.602	.002	.006	3	2
LUNG_SCLC	FOXA1 →	+3.840	+1.602	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN20 by Maintenance of apical/basal cell polarity activity — SKIN

Explore this box plot interactively →