Maintenance of apical/basal cell polarity

Across TCGA cell cohorts, RNA activity of the Maintenance of apical/basal cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDCD6IP, TWF2, and DYNC1I2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of apical/basal cell polarity activity versus PDCD6IP in CNS (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDCD6IP →	+1.582	+0.438	<.001	<.001	3	10
OVARY	TWF2 →	+2.460	+0.522	<.001	<.001	3	8
OVARY	DYNC1I2 →	+1.282	+0.418	<.001	<.001	3	8
OVARY	UBQLN1 →	+1.630	+0.607	<.001	<.001	3	8
OVARY	DYNC1LI1 →	+1.192	+0.442	<.001	<.001	3	8
LIVER	AIP →	+3.695	+0.435	.009	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035090 vs PDCD6IP — CNS

Explore this scatter interactively →