Axoneme assembly

Across TCGA patient cohorts, RNA activity of the Axoneme assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTC21B, WDR54, and IFT74, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axoneme assembly activity versus TTC21B in BRCA (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTC21B →	+0.311	+0.048	<.001	<.001	3	8
UCEC	WDR54 →	+0.569	+0.171	<.001	<.001	3	8
BRCA	IFT74 →	+0.472	+0.061	<.001	<.001	3	8
UCEC	IFT88 →	+0.532	+0.164	<.001	<.001	3	8
BRCA	WDR19 →	+0.564	+0.071	<.001	<.001	3	7
BRCA	WDR35 →	+0.439	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035082 vs TTC21B — BRCA

Explore this scatter interactively →