Axoneme assembly

Across TCGA patient cohorts, RNA activity of the Axoneme assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK9, SPAG1, and DYNLRB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axoneme assembly activity versus AK9 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AK9 →	+0.344	+0.287	.003	.008	3	6
HNSC	SPAG1 →	+0.569	+0.835	<.001	<.001	3	5
LSCC	DYNLRB2 →	+0.763	+0.505	<.001	<.001	3	5
LUAD	CLDN12 →	+0.578	+0.354	<.001	.005	3	4
LUAD	DNAI4 →	+0.606	+0.472	<.001	<.001	3	4
COAD	FAM20A →	-0.502	-0.349	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035082 vs AK9 — LSCC

Explore this scatter interactively →