Axoneme assembly

Across TCGA cell cohorts, RNA activity of the Axoneme assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAW1, PMS2, and RAB28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAW1 grouped by Axoneme assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DAW1 →	-0.447	-1.931	<.001	<.001	3	5
BLOOD_Myeloma	PMS2 →	-0.139	-1.190	<.001	.004	3	4
BLOOD_Myeloma	RAB28 →	+0.406	+1.822	.002	<.001	3	4
BLOOD_Myeloma	WDR27 →	-0.463	-2.019	.004	<.001	3	4
BLOOD_Myeloma	POMK →	-0.527	-1.955	<.001	<.001	3	4
BLOOD_Myeloma	DNAH5 →	-0.185	-1.190	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAW1 by Axoneme assembly activity — BLOOD_Leukemia

Explore this box plot interactively →