Embryonic heart tube development

Across TCGA patient cohorts, RNA activity of the Embryonic heart tube development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTM3, CYGB, and EEF2_T435, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic heart tube development activity versus GSTM3 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSTM3 →	+0.841	+0.020	.003	.006	3	8
CCRCC	CYGB →	+0.409	+0.039	<.001	<.001	3	7
COAD	EEF2_T435 →	-0.732	-0.035	.007	.001	2	8
LUAD	LARP4_S722 →	-0.391	-0.034	.008	.002	3	7
UCEC	TPPP3 →	+1.318	+0.050	<.001	<.001	3	7
BRCA	LARP4 →	-0.281	-0.026	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035050 vs GSTM3 — BRCA

Explore this scatter interactively →