Embryonic heart tube development

Across TCGA patient cohorts, RNA activity of the Embryonic heart tube development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS9-AS2, MOCS1, and GJB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic heart tube development activity versus ADAMTS9-AS2 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAMTS9-AS2 →	+0.432	+0.454	.005	<.001	3	5
BRCA	MOCS1 →	+0.593	+0.478	.003	.008	3	4
HNSC	GJB3 →	-0.812	-0.256	<.001	.005	3	4
LSCC	LINC01814 →	-0.527	-0.509	.001	.005	3	3
LSCC	TNC →	+1.125	+0.425	.005	<.001	3	3
OV	SHCBP1 →	-0.669	-0.608	.002	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035050 vs ADAMTS9-AS2 — LUAD

Explore this scatter interactively →