Embryonic heart tube development

Across TCGA cell cohorts, RNA activity of the Embryonic heart tube development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, MRPL46, and MARCKSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBI grouped by Embryonic heart tube development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TGFBI →	-4.495	-0.922	<.001	<.001	3	4
CNS	MRPL46 →	+0.486	+0.787	.005	<.001	3	3
BREAST	MARCKSL1 →	-1.565	-0.658	<.001	.002	3	3
SOFT_TISSUE	ETV6 →	-0.724	-0.807	.002	.004	3	3
OVARY	ZNF688 →	-0.484	-0.880	.001	.004	3	3
BLOOD_Myeloma	RER1 →	-0.988	-1.458	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBI by Embryonic heart tube development activity — CNS

Explore this box plot interactively →